BI-847325

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MEK/Aurora Inhibitor

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Catalog No. A15762

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BI-847325 5mg A15762-5

Regular Price: $105.00

Special Price: $89.25

BI-847325 10mg A15762-10

Regular Price: $180.00

Special Price: $153.00

BI-847325 25mg A15762-25

Regular Price: $360.00

Special Price: $306.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

BI-847325

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Chemical Information

Catalog Num A15762
Actions Inhibitor
M. Wt 464.56
Formula C29H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1207293-36-4
Synonyms BI 847325, BI847325
SMILES code CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O
Chemical Name (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

Biological Activity

Description
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Targets
Aurora B (Xenopus laevis) MEK2 Aurora C (Human) Aurora A (Human) MEK1
3 nM4 nM15 nM25 nM25 nM

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