BI-847325

Catalog No.: A15762
MEK/Aurora Inhibitor
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Grouped product items
Product Name Price Stock Qty
BI-847325 5mg
$105.00
In stock
BI-847325 10mg
$180.00
In stock
BI-847325 25mg
$360.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's BI-847325 has been cited by 3 publications
  • Hilda Samimi, .et al. , Cancer Cell Int, 2022, Dec 8;22(1):388 PMID: 36482411
  • Hilda Samimi, .et al. , Thyroid Res, 2021, Dec 3;14(1):27 PMID: 34861882
  • Hilda Samimi, .et al. , DARU J Pharm Sci, 2019, 1-7 PMID: 31077090
  • Biological Activity
    Discription BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
    Targets
    Target Value
    Product Information
    Catalog Num A15762
    Formula C29H28N4O2
    Molecular Weight 464.56
    CAS Number 1207293-36-4
    SMILES CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O
    Synonyms BI 847325, BI847325
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 19 mg/mL (40.89 mM)
    Water Insoluble
    Ethanol 1 mg/mL (2.15 mM)
    In vivo 2-hydroxyethyl cellulose, polysorbate 80 with pH adjusted to 2.8 with 1 M HCl 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.53 mL 107.63 mL 215.26 mL
    0.5 mM 4.31 mL 21.53 mL 43.05 mL
    1 mM 2.15 mL 10.76 mL 21.53 mL
    5 mM 0.43 mL 2.15 mL 4.31 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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