BIBR 953 (Dabigatran, Pradaxa)

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

Grouped product items
Product Name Price Stock Qty
BIBR 953 5mg
$80.00
In stock
BIBR 953 10mg
$140.00
In stock
BIBR 953 50mg
$450.00
In stock
BIBR 953 100mg
$720.00
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Adooq Products cited in reputable paper
Adooq's BIBR 953 (Dabigatran, Pradaxa) has been cited by 1 publications
  • Tanaka M, .et al. , J Pharmacol Sci, 2016, Jul;131(3):162-71 PMID: 27426918
  • Biological Activity
    Discription

    BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

    Targets
    Target Value
    Product Information
    Catalog Num A10138
    Formula C25H25N7O3
    Molecular Weight 471.5
    CAS Number 211914-51-1
    SMILES CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO <1 mg/mL
    Water 29 mg/mL (61.5 mM)
    Ethanol 0.01 mg/mL (0.02 mM)
    In vivo 10% Trifluoroacetic acid water solution 31 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.21 mL 106.04 mL 212.09 mL
    0.5 mM 4.24 mL 21.21 mL 42.42 mL
    1 mM 2.12 mL 10.6 mL 21.21 mL
    5 mM 0.42 mL 2.12 mL 4.24 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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