(E/Z)-BIX 02189

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Grouped product items
Product Name Stock
BIX 02189 5mg
BIX 02189 10mg
BIX 02189 50mg
BIX 02189 100mg
BIX 02189 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's (E/Z)-BIX 02189 has been cited by 1 publications
  • Mitsunori Miyazaki, .et al. , FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738
  • Biological Activity
    Discription BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A10151
    Formula C27H28N4O2
    Molecular Weight 440.5
    CAS Number 1094614-85-3
    SMILES CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 56 mg/mL (127.11 mM)
    Water Insoluble
    Ethanol 75 mg/mL (170.24 mM)
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.7 mL 113.51 mL 227.01 mL
    0.5 mM 4.54 mL 22.7 mL 45.4 mL
    1 mM 2.27 mL 11.35 mL 22.7 mL
    5 mM 0.45 mL 2.27 mL 4.54 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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