BIX 02189

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MEK inhibitor

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Catalog No. A10151

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BIX 02189 5mg A10151-5

Regular Price: $90.00

Special Price: $72.00

BIX 02189 10mg A10151-10

Regular Price: $160.00

Special Price: $128.00

BIX 02189 50mg A10151-50

Regular Price: $680.00

Special Price: $544.00

BIX 02189 100mg A10151-100

Regular Price: $980.00

Special Price: $784.00

BIX 02189 10mM * 1mL in DMSO A10151-10mM-D

Regular Price: $138.00

Special Price: $110.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

BIX 02189

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Chemical Information

Catalog Num A10151
Actions Inhibitor
M. Wt 440.5
Formula C27H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1094614-85-3
Synonyms BIX02189, BIX-02189
SMILES code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
Chemical Name 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

Biological Activity

Description
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Targets
Target Value
MEK5IC50: 1.5nM
ERK5IC50: 59nM
TGFβR1IC50: 580nM
MEK1IC50: >6.2μM
MEK2IC50: >6.2μM
ERK1IC50: >6.2μM
JNK2IC50: >6.2μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM

Solubility

Solubility (25°C) * In vitro DMSO 60 mg/mL heating (136.19 mM)
Water <1 mg/mL (<1 mM)
Ethanol 80 mg/mL (181.59 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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