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BMS-345541

Name: BMS-345541
Brand: Adooq Bioscience
SKU: A12559
Availability: InStock

Cat. No. A12559 CAS 445430-58-0

IKK2/IKK1 inhibitor

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM

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Biological Activity

Target & Activity

Target	Activity	Value
IKK2 (Cell-free assay)		0.3 μM
IKK1 (Cell-free assay)		4 μM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A549	IC50	5.6 μM	Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 27886548]
A549	IC50	8.6 μM	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
Jurkat	CC50	100 μM	Cytotoxicity against Jurkat cells by Alamar blue assay	[PMID: 17540562]
L02	IC50	15.3 μM	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
Lewis lung carcinoma cell line	IC50	4.8 μM	Cytotoxicity against mouse LLC cells measured after 72 hrs by MTT assay	[PMID: 27886548]
NCI-H1650	IC50	19.9 μM	Cytotoxicity against human NCI-H1650 cells measured after 72 hrs by MTT assay	[PMID: 27886548]
NCI-H1650	IC50	9.3 μM	Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H1975	IC50	8 μM	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
NCI-H460	IC50	2.8 μM	Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29655083]
PBMC	IC50	1000 nM	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release treated for 5 mins before LPS challenge measured after 6 hrs by ELISA	[PMID: 21087862]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	445430-58-0
Applications	IKK2/IKK1 inhibitor
Formula	C₁₄H₁₇N₅
Molecular Weight	255.32
SMILES	CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	8 mg/mL (31.32 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.