Gamma-secretase inhibitor

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Catalog No. A10157

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BMS-708163 5mg A10157-5

Regular Price: $110.00

Special Price: $88.00

BMS-708163 10mg A10157-10

Regular Price: $200.00

Special Price: $160.00

BMS-708163 50mg A10157-50

Regular Price: $680.00

Special Price: $544.00

BMS-708163 100mg A10157-100

Regular Price: $1,180.00

Special Price: $944.00

BMS-708163 10mM * 1mL in DMSO A10157-10mM-D

Regular Price: $174.00

Special Price: $139.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BMS-708163 is an oral gamma secretase inhibitor designed for selective
inhibition of amyloid beta synthesis.


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Chemical Information

Catalog Num A10157
Actions Inhibitor
M. Wt 520.8
Formula C20H17ClF4N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1146699-66-2
Synonyms BMS708163
SMILES code C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[[email protected]](CCC(F)(F)F)C(=O)N)Cl
Chemical Name (2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide

Biological Activity

BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
γ secretase(Aβ42) γ secretase(Aβ40)
0.27 nM0.3 nM


Solubility (25°C)* In vitro DMSO 104 mg/mL (199.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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