Target & Activity
| Target | Activity | Value |
|---|---|---|
| JNK3 | IC50 | 6 nM |
| JNK2 | IC50 | 7 nM |
| JNK1 | IC50 | 61 nM |
Fig. 1 · Structure
Documents & Downloads
Tanzisertib (CC-930)
Cat. No.
A13564
CAS
899805-25-5
JNK inhibitor
CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 899805-25-5 |
| Applications | JNK inhibitor |
| Formula | C21H23F3N6O2 |
| Molecular Weight | 448.44 |
| Synonyms | CC 930 |
| SMILES | C1COC[C@H]1N2C3=NC(=NC=C3N=C2NC4=C(C=C(C=C4F)F)F)NC5CCC(CC5)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 80 mg/mL (164.98 mM) |
| Water | Warmed: 4 mg/mL (8.24 mM) |
| Ethanol | Warmed: 80 mg/mL (164.98 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.