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Cerdulatinib

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multi-targeted tyrosine kinase inhibitor

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Catalog No. A14210

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cerdulatinib 10mg A14210-10

Regular Price: $90.00

Special Price: $72.00

Cerdulatinib 25mg A14210-25

Regular Price: $200.00

Special Price: $160.00

Cerdulatinib 50mg A14210-50

Regular Price: $350.00

Special Price: $280.00

Cerdulatinib 10mM * 1mL in DMSO A14210-10mM-D

Regular Price: $102.00

Special Price: $81.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.

Cerdulatinib

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Chemical Information

Catalog Num A14210
Actions Inhibitor
M. Wt 482
Formula C20H28ClN7O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1369761-01-2
Synonyms PRT062070, PRT2070, PRT-2070
SMILES code CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl
Chemical Name 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)

Biological Activity

Description
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
Targets
Target Value
TYK2IC50: 0.5nM
MST1IC50: 4nM
ARK5IC50: 4nM
MLK1IC50: 5nM
FmsIC50: 5nM
AMPKIC50: 6nM
JAK2IC50: 6nM
JAK3IC50: 8nM
TBK1IC50: 10nM
MARK1IC50: 10nM
JAK1IC50: 12nM
PAR1B-aIC50: 13nM
TSSKIC50: 14nM
MST2IC50: 15nM
GCKIC50: 18nM
JNK3IC50: 18nM
RSK2IC50: 20nM
RSK4IC50: 28nM
SykIC50: 32nM
Chk1IC50: 42nM
FLT4IC50: 51nM
FLT3IC50: 90nM
RETIC50: 105nM
ITKIC50: 194nM

Solubility

Solubility (25°C)* In vitro DMSO 43 mg/mL heating (89.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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