CK-1827452 (Omecamtiv mecarbil)

CK-1827452 is a selective cardiac specific myosin activator.
Grouped product items
Product Name Price Stock Qty
CK-1827452 5mg
$90.00
In stock
CK-1827452 10mg
$160.00
In stock
CK-1827452 50mg
$480.00
In stock
CK-1827452 100mg
$880.00
In stock
CK-1827452 10mM * 1mL in DMSO
$131.00
In stock
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Adooq Products cited in reputable paper
Adooq's CK-1827452 (Omecamtiv mecarbil) has been cited by 11 publications
  • Oleg Lookin, .et al. , Clin Exp Pharmacol Physiol, 2021, Aug 29 PMID: 34459025
  • Gabor A. Fulop, .et al. , Basic Res Cardiol, 2021, 116(1): 24 PMID: 33844095
  • Wanjian Tang, .et al. , J Biol Chem, 2019, October 2 PMID: 31578282
  • Thinh T. Kieu, .et al. , Biophysical Journal, 2019, 2019 PMID: 31103235
  • Alexandre J. S. Ribeiro, .et al. , Circ Res, 2017, May 12; 120(10): 1572-1583 PMID: 28400398
  • Anja M. Swenson, .et al. , J Biol Chem, 2017, Mar 3; 292(9): 3768-3778 PMID: 28082673
  • Nánási P Jr, .et al. , Eur J Pharmacol, 2017, Aug 15;809:73-79 PMID: 28506910
  • Horváth B, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 PMID: 28940010
  • Szentandrassy N, .et al. , J Physiol Pharmacol, 2016, Aug;67(4):483-489 PMID: 27779469
  • L Nagy, .et al. , Br J Pharmacol, 2015, Sep; 172(18): 4506-4518 PMID: 26140433
  • Larissa Butler, .et al. , Toxicol Sci, 2015, Jun;145(2):396-406 PMID: 25820236
  • Biological Activity
    Discription CK-1827452 is a selective cardiac specific myosin activator.
    Targets
    Target Value
    Product Information
    Catalog Num A11206
    Formula C20H24FN5O3
    Molecular Weight 401.43
    CAS Number 873697-71-3
    SMILES CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
    Synonyms CK1827452, Omecamtiv Mecarbil
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 73 mg/mL (181.84 mM)
    Water Insoluble
    Ethanol 5 mg/mL (12.45 mM)
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.91 mL 124.55 mL 249.11 mL
    0.5 mM 4.98 mL 24.91 mL 49.82 mL
    1 mM 2.49 mL 12.46 mL 24.91 mL
    5 mM 0.5 mL 2.49 mL 4.98 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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