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Fig. 1 · Structure
Cat. No.
A12601
CAS No.
117048-59-6
Formula
C18H20O5
Mol. Weight
316.35

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Combretastatin A4

Cat. No. A12601 CAS 117048-59-6
Combretastatin A4 is an antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
518A2 IC50 0.02 μM Cytotoxicity against human 518A2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay [PMID: 31958738]
518A2 IC50 1.8 nM Growth inhibition of human 518A2 cells after 72 hrs by MTT assay [PMID: 27116710]
518A2 IC50 18 nM Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay [PMID: 20731355]
786-0 GI50 0.1 μM Growth inhibition of human 786-0 cells after 48 hrs by SRB assay [PMID: 24387982]
786-0 GI50 0.1 μM Growth inhibition of human 786-0 cells after 48 hrs by SRB assay [PMID: 22982122]
786-0 GI50 0.1 μM Cytotoxicity against human 786-0 cells by SRB assay [PMID: 26257861]
786-0 GI50 100 nM Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay [PMID: 24388833]
A10 EC50 < 0.025 μM Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique [PMID: 20006519]
A10 EC50 0.007 μM Antiproliferative activity against rat A10 cells assessed as microtubule depolymerization after 18 to 24 hrs by indirect immunofluorescence technique [PMID: 19894742]
A10 IC50 1 nM Growth inhibition of rat A10 cells after 48 hrs by MTT assay [PMID: 22044164]
A10 EC50 13 nM Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by indirect immunofluorescence assay [PMID: 23332369]
A10 EC50 7 nM Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay [PMID: 23895532]
A10 EC50 9.8 nM Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence method [PMID: 30098869]
A10 EC50 9.8 nM Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay [PMID: 25882519]
A2780 IC50 0.003 μM Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay [PMID: 31185410]
A2780 IC50 0.004 μM Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay [PMID: 35065411]
A2780 IC50 0.004 μM Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay [PMID: 33581556]
A2780 IC50 0.005 μM Antiproliferative activity against human A2780 cells by MTT assay [PMID: 29126741]
A2780 IC50 0.006 μM Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay [PMID: 29306206]
A2780 IC50 0.009 μM Cytotoxicity against human A2780 cells assessed as cell viability after 48 hrs by MTT assay [PMID: 27149641]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 117048-59-6
Formula C18H20O5
Molecular Weight 316.35
Synonyms CRC 87-09; NSC 817373
SMILES
COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 58 mg/mL (183.34 mM)
Water Insoluble
Ethanol Warmed: 31 mg/mL (97.99 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
28 mg/mL
Vehicle
5% DMSO+50% PEG 300+ddH2O

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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