CP-690550 (Tofacitinib citrate) ON SALE JAK-3 inhibitor

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Catalog No. A10241

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CP-690550 10mg A10241-10

Regular Price: $60.00

Special Price: $51.00

CP-690550 50mg A10241-50

Regular Price: $220.00

Special Price: $187.00

CP-690550 100mg A10241-100

Regular Price: $380.00

Special Price: $323.00

CP-690550 10mM * 1mL in DMSO A10241-10mM-D

Regular Price: $89.00

Special Price: $75.65

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.

CP-690550 (Tofacitinib citrate)

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Chemical Information

Catalog Num A10241
Actions Inhibitor
M. Wt 504.5
Formula C16H20N6O.C6H8O7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 540737-29-9
Synonyms CP690550, tasocitinib citrate, CP-690,550
SMILES code C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Name 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt

Biological Activity

Description
CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
Targets
Target Value
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAPK2IC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (198.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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