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Fig. 1 · Structure
Cat. No.
A11173
CAS No.
186392-40-5
Formula
C21H22ClN3O3
Mol. Weight
399.87

Documents & Downloads

CP-91149

Cat. No. A11173 CAS 186392-40-5

HLGP Inhibitor

CP-91149 is a selective glycogen phosphorylase inhibitor.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
Glycogen phosphorylase (GP) 0.13 μM

Cellular Effect

Cell Line Activity Value Description Reference
Hepatocyte IC50 3172.5 nM Inhibition of glycogenolysis in rat hepatocytes assessed as GCN-stimulated glycogen breakdown after 5 mins [PMID: 32527535]
HepG2 IC50 3310.4 nM Inhibition of glycogenolysis in human HepG2 cells assessed as GCN-stimulated glycogen breakdown after 5 mins [PMID: 32527535]
Sf9 IC50 0.082 μM Inhibition of human recombinant liver glycogen phosphorylase A expressed in baculovirus infected Sf9 insect cells assessed as release of phosphate from glucose-1- phosphate in presence of 7.5 mM glucose by malachite green based assay [PMID: 27624527]
Sf9 IC50 110 nM Inhibition of recombinant human liver glycogen phosphorylase a expressed in baculovirus-infected Sf9 cells using glucose-1-phosphate as substrate in presence of 7.5 mM glucose [PMID: 32527535]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 186392-40-5
Applications HLGP Inhibitor
Formula C21H22ClN3O3
Molecular Weight 399.87
SMILES
CN(C)C(=O)[C@@H]([C@H](CC1=CC=CC=C1)NC(=O)C2=CC3=C(N2)C=CC(=C3)Cl)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 74 mg/mL (185.06 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
4 mg/mL
Vehicle
0.5% methylcellulose+0.2% Tween 80

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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