Phosphorylases

Cat. No.

A11847

CAS No.

3094-09-5

Doxifluridine

Synonyms: Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR

Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

Cat. No.

A11173

CAS No.

186392-40-5

CP-91149

CP-91149 is a selective glycogen phosphorylase inhibitor.

Cat. No.

A13098

CAS No.

183204-72-0

Tipiracil hydrochloride

Tipiralacil hydrochloride, also known as TPI, is a thymidine phosphorylase inhibitor (TPI).

Cat. No.

A13897

CAS No.

97161-97-2

K252a

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively).

Cat. No.

A20793

CAS No.

186392-65-4

Ingliforib (CP 368296, GPi 296)

Synonyms: CP 368296; GPi 296

Ingliforib is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

Cat. No.

A77225

CAS No.

186392-43-8

CP-316819

Synonyms: GPi 819

CP-316819 is a potent inhibitor of glycogen phosphorylase (GPase), demonstrating significant antihyperglycemic activity with IC50 values of 17 nM and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa), respectively. This compound promotes glycogen accumulation under normoglycemic conditions while allowing glycogen utilization during low glucose availability. Additionally, CP-316819 has been shown to prevent neuronal cell death and sustain brain electrical activity, making it a valuable tool for research into metabolic regulation and neuroprotection.

Cat. No.

A77231

CAS No.

648926-15-2

Glycogen phosphorylase-IN-1

Glycogen phosphorylase-IN-1 is a potent inhibitor of human liver glycogen phosphorylase (hlGPa), demonstrating IC50 values of 53 nM for the enzyme and 380 nM for glucose production from hepatocyte glycogen. This compound is particularly relevant for research applications targeting type 2 diabetes, as it effectively reduces glycogen-derived glucose production in hepatocytes, thereby influencing glucose homeostasis.

Cat. No.

A77232

CAS No.

100276-03-7

BAY R3401

BAY R3401 is an orally active inhibitor of glycogen phosphorylase, demonstrating irreversible and non-selective inhibition of hepatic glycogenolysis. This compound effectively inhibits glycogenolysis in liver cells, exhibiting IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 serves as a valuable tool for research focused on type 2 diabetes and its associated metabolic pathways.

Cat. No.

A77233

CAS No.

918902-32-6

GPi688

GPi688 is a potent and orally active inhibitor of glycogen phosphorylase (GPa), demonstrating IC50 values of 19 nM, 61 nM, and 12 nM for human liver GPa, rat liver GPa, and human skeletal muscle GPa, respectively. This compound effectively inhibits glucagon-mediated glucose output in rat primary hepatocytes. GPi688 is a valuable tool for investigating glucagon-mediated hyperglycemia and related metabolic disorders in research applications.

Cat. No.

A77234

CAS No.

402491-35-4

Deoxyadenosine diphosphate sodium

Deoxyadenosine diphosphate sodium is a nucleoside diphosphate that functions as a phosphorylase inhibitor. It plays a crucial role in DNA synthesis and repair processes by inhibiting polynucleotide phosphorylase, thereby interfering with the polymerization of ADP and CDP. This compound is valuable for research applications focused on understanding DNA metabolism and enzymatic regulation in cellular systems.

Cat. No.

B18123

CAS No.

22423-26-3

TK-112690

TK-112690 is a selective inhibitor of uridine phosphorylase 1 (UPP1). It demonstrates inhibitory effects on murine small intestinal uridine phosphorylase with an IC50 of 12.5 μM and on human small intestinal UPP1 with an IC50 of 20.0 μM in vitro. By increasing plasma uridine concentration in mice, TK-112690 can be utilized to explore therapeutic avenues in cancer research and pulmonary fibrosis studies.