Danusertib (PHA-739358)

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Aurora inhibitor

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Catalog No. A10715

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Danusertib 5mg A10715-5

Regular Price: $100.00

Special Price: $85.00

Danusertib 10mg A10715-10

Regular Price: $180.00

Special Price: $153.00

Danusertib 25mg A10715-25

Regular Price: $350.00

Special Price: $297.50

Danusertib 50mg A10715-50

Regular Price: $560.00

Special Price: $476.00

Danusertib (PHA-739358) 10mM * 1mL in DMSO A10715-10mM-D

Regular Price: $120.00

Special Price: $102.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Danusertib (PHA-739358) is a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor

Danusertib (PHA-739358)

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Chemical Information

Catalog Num A10715
Actions Inhibitor
M. Wt 474.6
Formula C26H30N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 827318-97-8
Synonyms PHA739358
SMILES code CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC
Chemical Name N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

Biological Activity

Description
Danusertib (PHA-739358) is a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor
Targets
Target Value
AuroraAIC50: 13nM
AblIC50: 25nM
RETIC50: 31nM
TrkAIC50: 31nM
FGFR1IC50: 47nM
AuroraCIC50: 61nM
AuroraBIC50: 79nM

Solubility

Solubility (25°C) * In vitro DMSO 95 mg/mL (200.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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