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|Storage||at -20°C 3 years Powder|
|SMILES code||C[[email protected]@H](C(=O)N[[email protected]@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F|
|Chemical Name||N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester|
|DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.|
|Solubility (25°C) *||In vitro||DMSO||86 mg/mL (198.86 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||50 mg/mL (115.61 mM)|
|In vivo||5% DMSO/95% Corn oil||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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