DAPT (GSI-IX)

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Gamma secretase inhibitor

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Catalog No. A10288

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
DAPT (GSI-IX) 5mg A10288-5

Regular Price: $40.00

Special Price: $32.00

DAPT (GSI-IX) 10mg A10288-10

Regular Price: $70.00

Special Price: $56.00

DAPT (GSI-IX) 50mg A10288-50

Regular Price: $250.00

Special Price: $200.00

DAPT (GSI-IX) 100mg A10288-100

Regular Price: $400.00

Special Price: $320.00

DAPT (GSI-IX) 10mM * 1mL in DMSO A10288-10mM-D

Regular Price: $94.00

Special Price: $75.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

DAPT (GSI-IX)

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Chemical Information

Catalog Num A10288
Actions Inhibitor
M. Wt 432.5
Formula C23H26F2N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 208255-80-5
Synonyms GSIIX
SMILES code C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Chemical Name N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester

Biological Activity

Description
DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
Targets
Aβ (HEK 293 cells) γ secretase(Aβ) (HEK 293 cells)
20 nM20 nM

Solubility

Solubility (25°C) * In vitro DMSO 86 mg/mL (198.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol 50 mg/mL (115.61 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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