FGFR

Cat. No.

A10080

CAS No.

943319-70-8

Ponatinib (AP24534)

Synonyms: AP24534

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor.

Cat. No.

A10699

CAS No.

635702-64-6

Pazopanib HCl (GW786034)

Synonyms: GW786034

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Cat. No.

A11159

CAS No.

872511-34-7

Infigratinib (BGJ398)

Synonyms: BGJ-398

BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively).

Cat. No.

A10137

CAS No.

656247-17-5

Nintedanib (Bibf1120)

Synonyms: Vargatef; Bibf1120

BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR.

Cat. No.

A11518

CAS No.

444731-52-6

Pazopanib (GW-786034)

Synonyms: GW 786034; Votrient

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Cat. No.

A10254

CAS No.

649735-46-6

Brivanib (BMS-540215)

Synonyms: BMS-540215

Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.

Cat. No.

A10953

CAS No.

252916-29-3

Orantinib (TSU-68, SU6668)

Synonyms: TSU68; SU6668

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.

Cat. No.

A11075

CAS No.

1035270-39-3

Fexagratinib (AZD4547)

Synonyms: AZD-4547

Fexagratinib (AZD4547) is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively.

Cat. No.

A16197

CAS No.

656247-18-6

Nintedanib esylate

Synonyms: BIBF-1120 esylate

Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs).

Cat. No.

A10703

CAS No.

219580-11-7

PD173074

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

Cat. No.

A10715

CAS No.

827318-97-8

Danusertib (PHA-739358)

Synonyms: PHA-739358

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2

Cat. No.

A11411

CAS No.

405169-16-6

Dovitinib (TKI-258)

Synonyms: CHIR-258; TKI258

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.

Cat. No.

A11558

CAS No.

215543-92-3

SU-5402

SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).

Cat. No.

A13111

CAS No.

882531-87-5

R1530

R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2.

Cat. No.

A15848

CAS No.

1637735-84-2

FIIN-3

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor.

Cat. No.

A20550

CAS No.

1448169-71-8

Futibatinib

Synonyms: TAS-120

Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor.

Cat. No.

A10162

CAS No.

649735-63-7

Brivanib alaninate (BMS-582664)

Synonyms: BMS-582664

Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.

Cat. No.

A10198

CAS No.

852433-84-2

Dovitinib Dilactic acid (CHIR-258 dilactic acid, TKI258 Dilactic acid)

Synonyms: CHIR-258; TKI258 Dilactic acid; CHIR-258 dilactic acid

Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.

Cat. No.

A10508

CAS No.

1000669-72-6

KW-2449

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.

Cat. No.

A11244

CAS No.

1254473-64-7

LY 2874455

LY2874455 is a novel and potent FGFR/VEGFR Inhibitor.

Cat. No.

A11753

CAS No.

917879-39-1

MK-2461

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

Cat. No.

A12357

CAS No.

1633044-56-0

FIIN-2

FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.

Cat. No.

A12486

CAS No.

705946-27-6

XL 999 (Tyrosine kinase-IN-1)

Synonyms: Tyrosine kinase-IN-1

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.

Cat. No.

A13069

CAS No.

898280-07-4

XL-228

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

Cat. No.

A13211

CAS No.

848318-25-2

SSR128129E

Synonyms: SSR

SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 uM