Pazopanib HCl (GW786034)

Catalog No.: A10699

VEGFR/PDGFR/FGFR inhibitor

Pazopanib HCl (GW786034) Chemical Structure

CAS NO. 635702-64-6

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$60.00
50 mg
$100.00
100 mg
$150.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
Target Value
VEGFR1IC50: 10nM
VEGFR2IC50: 30nM
VEGFR3IC50: 47nM
FGFRIC50: 74nM
PDGFRIC50: 84nM
c-KitIC50: 140nM
c-FmsIC50: 146nM
In vitro (25°C) DMSO 17 mg/mL (35.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.49 mL 210.97 mL
0.5 mM 4.22 mL 21.1 mL 42.19 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10699
Actions Inhibitor
M. Wt 474.0
Formula C21H23N7O2S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 635702-64-6
Synonyms GW786034, GW-786034
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl

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