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Pazopanib HCl (GW786034)



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Catalog No. A10699

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Pazopanib Hydrochloride 10mg A10699-10

Regular Price: $40.00

Special Price: $36.00

Pazopanib Hydrochloride 25mg A10699-25

Regular Price: $60.00

Special Price: $54.00

Pazopanib Hydrochloride 50mg A10699-50

Regular Price: $100.00

Special Price: $90.00

Pazopanib Hydrochloride 100mg A10699-100

Regular Price: $150.00

Special Price: $135.00

Pazopanib HCl (GW786034) 10mM * 1mL in DMSO A10699-10mM-D

Regular Price: $50.00

Special Price: $45.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Pazopanib HCl (GW786034)

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Chemical Information

Catalog Num A10699
Actions Inhibitor
M. Wt 474.0
Formula C21H23N7O2S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 635702-64-6
Synonyms GW786034, GW-786034
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl

Biological Activity

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Target Value
VEGFR1IC50: 10nM
VEGFR2IC50: 30nM
VEGFR3IC50: 47nM
FGFRIC50: 74nM
c-KitIC50: 140nM
c-FmsIC50: 146nM


Solubility (25°C) * In vitro DMSO 17 mg/mL (35.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.49 mL 210.97mL
0.5 mM 4.22 mL 21.1 mL 42.19 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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