Pazopanib HCl (GW786034)

Catalog No.: A10699

VEGFR/PDGFR/FGFR inhibitor

Pazopanib HCl (GW786034)

Pazopanib HCl (GW786034) Chemical Structure

CAS NO. 635702-64-6

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

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10 mg

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25 mg

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50 mg

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Special Price $80.00

100 mg

Regular Price: $150.00

Special Price $120.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $40.00

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  • Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Biological Activity

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
Target Value
VEGFR1IC50: 10nM
VEGFR2IC50: 30nM
VEGFR3IC50: 47nM
FGFRIC50: 74nM
PDGFRIC50: 84nM
c-KitIC50: 140nM
c-FmsIC50: 146nM
In vitro (25°C) DMSO 15 mg/mL (31.64 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.1 mL 105.49 mL 210.97 mL
0.5 mM 4.22 mL 21.1 mL 42.19 mL
1 mM 2.11 mL 10.55 mL 21.1 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10699
Actions Inhibitor
CAS No. 635702-64-6
Formula C21H23N7O2S.HCl
M. Wt 474.0
Purity >98%
Synonyms GW786034, GW-786034
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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