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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
- Hideharu Yamada, .et al. lncRNA HAR1B has potential to be a predictive marker for pazopanib therapy in patients with sarcoma, Oncol Lett, 2021, Jun;21(6):455 PMID: 33907565
- Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
Biological Activity
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
Target | Value |
---|---|
VEGFR1 | IC50: 10nM |
VEGFR2 | IC50: 30nM |
VEGFR3 | IC50: 47nM |
FGFR | IC50: 74nM |
PDGFR | IC50: 84nM |
c-Kit | IC50: 140nM |
c-Fms | IC50: 146nM |
In vitro (25°C) | DMSO | 15 mg/mL (31.64 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.1 mL | 105.49 mL | 210.97 mL |
0.5 mM | 4.22 mL | 21.1 mL | 42.19 mL |
1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10699 |
---|---|
Actions | Inhibitor |
CAS No. | 635702-64-6 |
Formula | C21H23N7O2S.HCl |
M. Wt | 474.0 |
Purity | >98% |
Synonyms | GW786034, GW-786034 |
SMILES | CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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