Pazopanib HCl (GW786034)

Name: Pazopanib HCl (GW786034)
Brand: Adooq Bioscience
SKU: A10699
Rating: 100 (4 reviews)

Catalog No.: A10699

VEGFR/PDGFR/FGFR inhibitor

Product Citations (4)

Pazopanib HCl (GW786034) Chemical Structure

CAS NO. 635702-64-6

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Availability: In stock

Package	Price	Qty
10 mg	$40.00
25 mg	$60.00
50 mg	$100.00
100 mg	$150.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Bulk Inquiry

Get Free Sample

Price Match

Add to Wishlist

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Pazopanib HCl (GW786034)

Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
Hideharu Yamada, .et al. lncRNA HAR1B has potential to be a predictive marker for pazopanib therapy in patients with sarcoma, Oncol Lett, 2021, Jun;21(6):455 PMID: 33907565
Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Biological Activity

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Targets

Target	Value
VEGFR1	IC50: 10nM
VEGFR2	IC50: 30nM
VEGFR3	IC50: 47nM
FGFR	IC50: 74nM
PDGFR	IC50: 84nM
c-Kit	IC50: 140nM
c-Fms	IC50: 146nM

Solubility *

In vitro (25°C)	DMSO	15 mg/mL (31.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.1 mL	105.49 mL	210.97 mL
0.5 mM	4.22 mL	21.1 mL	42.19 mL
1 mM	2.11 mL	10.55 mL	21.1 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10699
Actions	Inhibitor
CAS No.	635702-64-6
Formula	C21H23N7O2S.HCl
M. Wt	474.0
Purity	>98%
Synonyms	GW786034, GW-786034
SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.