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Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
| Target | Value |
|---|---|
| VEGFR1 | IC50: 10nM |
| VEGFR2 | IC50: 30nM |
| VEGFR3 | IC50: 47nM |
| FGFR | IC50: 74nM |
| PDGFR | IC50: 84nM |
| c-Kit | IC50: 140nM |
| c-Fms | IC50: 146nM |
| In vitro (25°C) | DMSO | 17 mg/mL (35.86 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.1 mL | 105.49 mL | 210.97 mL |
| 0.5 mM | 4.22 mL | 21.1 mL | 42.19 mL |
| 1 mM | 2.11 mL | 10.55 mL | 21.1 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 474.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10699 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 474.0 |
| Formula | C21H23N7O2S.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 635702-64-6 |
| Synonyms | GW786034, GW-786034 |
| SMILES | CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl |
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