PD173074

Name: PD173074
Brand: Adooq Bioscience
SKU: A10703
Rating: 100 (1 reviews)

Catalog No.: A10703

FGFR1/VEGFR2 Inhibitor

Product Citations (1)

PD173074 Chemical Structure

CAS NO. 219580-11-7

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

Availability: In stock

Package	Price	Qty
5 mg	$30.00
10 mg	$50.00
50 mg	$140.00
100 mg	$220.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq PD173074

Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257-272 PMID: 26862703

Biological Activity

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

Targets

Target	Value
FGFR1	IC50: ~25nM
VEGFR2	IC50: 100nM-200nM
c-Src	IC50: 19.8μM
EGFR	IC50: >50μM
Insulin Receptor	IC50: >50μM
MEK	IC50: >50μM
PKC	IC50: >50μM

Solubility *

In vitro (25°C)	DMSO	86 mg/mL (164.22 mM)
	Water	Insoluble
	Ethanol	86 mg/mL (164.22 mM)
In vivo	5% DMSO+corn oil	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.09 mL	95.47 mL	190.95 mL
0.5 mM	3.82 mL	19.09 mL	38.19 mL
1 mM	1.91 mL	9.55 mL	19.09 mL
5 mM	0.38 mL	1.91 mL	3.82 mL

*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10703
Actions	Inhibitor
CAS No.	219580-11-7
Formula	C28H41N7O3
M. Wt	523.7
Purity	>98%
Synonyms	PD-173074
SMILES	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.