Catalog No.: A10703

FGFR1/VEGFR2 Inhibitor


PD173074 Chemical Structure

CAS NO. 219580-11-7

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

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10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257-272 PMID: 26862703

Biological Activity

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Target Value
FGFR1IC50: ~25nM
VEGFR2IC50: 100nM-200nM
c-SrcIC50: 19.8μM
EGFRIC50: >50μM
Insulin ReceptorIC50: >50μM
MEKIC50: >50μM
PKCIC50: >50μM
In vitro (25°C) DMSO 86 mg/mL (164.22 mM)
Water Insoluble
Ethanol 86 mg/mL (164.22 mM)
In vivo 5% DMSO+corn oil 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.09 mL 95.47 mL 190.95 mL
0.5 mM 3.82 mL 19.09 mL 38.19 mL
1 mM 1.91 mL 9.55 mL 19.09 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10703
Actions Inhibitor
CAS No. 219580-11-7
Formula C28H41N7O3
M. Wt 523.7
Purity >98%
Synonyms PD-173074

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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