- Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257-272 PMID: 26862703
Biological Activity
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Targets
Target | Value |
---|---|
FGFR1 | IC50: ~25nM |
VEGFR2 | IC50: 100nM-200nM |
c-Src | IC50: 19.8μM |
EGFR | IC50: >50μM |
Insulin Receptor | IC50: >50μM |
MEK | IC50: >50μM |
PKC | IC50: >50μM |
In vitro (25°C) | DMSO | 86 mg/mL (164.22 mM) | |
Water | Insoluble | ||
Ethanol | 86 mg/mL (164.22 mM) | ||
In vivo | 5% DMSO+corn oil | 14 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.09 mL | 95.47 mL | 190.95 mL |
0.5 mM | 3.82 mL | 19.09 mL | 38.19 mL |
1 mM | 1.91 mL | 9.55 mL | 19.09 mL |
5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10703 |
---|---|
Actions | Inhibitor |
CAS No. | 219580-11-7 |
Formula | C28H41N7O3 |
M. Wt | 523.7 |
Purity | >98% |
Synonyms | PD-173074 |
SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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