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PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Targets
| Target | Value |
|---|---|
| FGFR1 | IC50: ~25nM |
| VEGFR2 | IC50: 100nM-200nM |
| c-Src | IC50: 19.8μM |
| EGFR | IC50: >50μM |
| Insulin Receptor | IC50: >50μM |
| MEK | IC50: >50μM |
| PKC | IC50: >50μM |
| In vitro | DMSO | 100 mg/mL (190.95 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (190.95 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.09 mL | 95.47 mL | 190.95 mL |
| 0.5 mM | 3.82 mL | 19.09 mL | 38.19 mL |
| 1 mM | 1.91 mL | 9.55 mL | 19.09 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10703 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 523.7 |
| Formula | C28H41N7O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 219580-11-7 |
| Synonyms | PD-173074 |
| SMILES | CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C |
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