Nintedanib esylate

Catalog No.: A16197

RTK inhibitor

Nintedanib esylate

Nintedanib esylate Chemical Structure

CAS NO. 656247-18-6

Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs).

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10 mg
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50 mg
$90.00
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  • Thibaut Fourniols, .et al. Inhibition of Colorectal Cancer-Associated Fibroblasts by Lipid Nanocapsules Loaded With Acriflavine or Paclitaxel, Int J Pharm, 2020, Jun 30;584:119337 PMID: 32371002
  • Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Biological Activity

Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs).
In vitro DMSO 89 mg/mL (136.97 mM)
Water 89 mg/mL (136.97 mM)
Ethanol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.39 mL 76.95 mL 153.9 mL
0.5 mM 3.08 mL 15.39 mL 30.78 mL
1 mM 1.54 mL 7.7 mL 15.39 mL
5 mM 0.31 mL 1.54 mL 3.08 mL

*The above data is based on the productmolecular weight 649.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16197
Actions Inhibitor
CAS No. 656247-18-6
Formula C33H39N5O7S
M. Wt 649.76
Purity >98%
Synonyms BIBF-1120 esylate
SMILES O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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