FTI 277

FTase inhibitor

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Catalog No. A12368

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
FTI 277 5mg A12368-5
$90.00
FTI 277 10mg A12368-10
$160.00
FTI 277 25mg A12368-25
$300.00
FTI 277 50mg A12368-50
$500.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

FTI 277

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Chemical Information

Catalog Num A12368
Actions Inhibitor
M. Wt 561.64
Formula C22H29N3O3S2.C2HF3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 170006-73-2
Synonyms FTI-277,FTI277
SMILES code CSCC[[email protected]](NC(=O)C1CCC(NC[[email protected]@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F
Chemical Name N-[4-[2(R)-Amino-3-mercaptopropyl]a?mino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt

Biological Activity

Description
FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

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