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|Storage||at -20°C 3 years Powder|
|SMILES code||CSCC[[email protected]](NC(=O)C1CCC(NC[[email protected]@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F|
|Chemical Name||N-[4-[2(R)-Amino-3-mercaptopropyl]a?mino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt|
|FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.|
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