GF 109203X

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PKC inhibitor

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Catalog No. A13197

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GF 109203X 10mg A13197-10

Regular Price: $120.00

Special Price: $96.00

GF 109203X 25mg A13197-25

Regular Price: $240.00

Special Price: $192.00

GF 109203X 50mg A13197-50

Regular Price: $450.00

Special Price: $360.00

GF 109203X 100mg A13197-100

Regular Price: $850.00

Special Price: $680.00

GF 109203X 10mM * 1mL in DMSO A13197-10mM-D

Regular Price: $100.00

Special Price: $80.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

GF 109203X

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Chemical Information

Catalog Num A13197
Actions Inhibitor
M. Wt 412.49
Formula C25H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 133052-90-1
Synonyms GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILES code CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
Chemical Name 2-[1-(3-Dimethylaminopropyl)indol-3?-yl]-3-(indol-3-yl) maleimide

Biological Activity

Description
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM

Solubility

Solubility (25°C)* In vitro DMSO 82 mg/mL (198.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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