Protein Kinase A (PKA)

Cat. No.

A11034

CAS No.

552325-73-2

A-674563

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Cat. No.

A11935

CAS No.

130964-39-5

H 89 2HCl

H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase.

Cat. No.

A15914

CAS No.

16980-89-5

Bucladesine sodium (DBcAMP sodium)

Synonyms: Dibutyryl cAMP sodium; DBcAMP sodium

Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.

Cat. No.

A16031

CAS No.

201422-03-9

PKI 14-22 amide, myristoylated

Synonyms: PKI (14-22) amide (myristoylated)

PKI 14-22 amide, myristoylated is a useful heat stable cAMP-dependent protein kinase inhibitor. This is often used to study PKA in cellular systems in-vitro.

Cat. No.

A10286

CAS No.

486-35-1

Daphnetin

Synonyms: 7,8-dihydroxycoumarin

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.

Cat. No.

A12464

CAS No.

1056901-62-2

AT13148

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.

Cat. No.

A12716

CAS No.

927871-76-9

S107

S107 is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

Cat. No.

A13584

CAS No.

78957-85-4

A-3 Hydrochloride

A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).

Cat. No.

A13608

CAS No.

1186648-22-5

MK-2 Inhibitor III

MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.

Cat. No.

A14307

CAS No.

278603-08-0

NH125

NH125 is a selective eEF-2 kinase inhibitor.

Cat. No.

A14868

CAS No.

121932-06-7

PKA inhibitor fragment (6-22) amide

PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor.

Cat. No.

A15006

CAS No.

1431697-86-7

AT7867 2HCl

Synonyms: AT-7867 dihydrochloride

AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.

Cat. No.

A15680

CAS No.

521-32-4

Bilobetin

Bilobetin acts as a PPARα activator, enhancing lipid metabolism and insulin sensitivity. It effectively reduces blood lipid levels by promoting hepatic lipid uptake and oxidation, while decreasing triglyceride secretion and accumulation in tissues. Additionally, Bilobetin stimulates the phosphorylation and nuclear translocation of PPARα, resulting in increased cAMP levels and PKA activity. This compound is significant for research in metabolic disorders, particularly those related to insulin resistance and lipid regulation.

Cat. No.

A15910

CAS No.

76939-46-3

8-Bromo-cAMP sodium salt

Synonyms: 8-Bromo-cAMP; sodium salt

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator.

Cat. No.

A16016

CAS No.

108068-98-0

KT 5720

KT 5720 is prepared by a modificiation of K-252a (sc-200517), which is synthesized by the fungus Nocardiopsis sp.

Cat. No.

A16017

CAS No.

1135306-29-4

6-Bnz-cAMP sodium salt

6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways.

Cat. No.

A16028

CAS No.

151837-09-1

cAMPS-Rp, triethylammonium salt

Synonyms: Rp-cAMPS

Rp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). Rp-cAMPS is resistant to hydrolysis by phosphodiesterases and is noncompetitive with respect to ATP.

Cat. No.

A16052

CAS No.

82801-73-8

cGMP Dependent Kinase Inhibitor Peptid

Synonyms: PKG Inhibitor

cGMP Dependent Kinase Inhibitor Peptid is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum.

Cat. No.

A16189

CAS No.

1813527-81-9

CCG215022

CCG215022 is a potent GRK2 and GRK5 inhibitor. CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.

Cat. No.

A16222

CAS No.

162758-94-3

Synaptamide

Synonyms: Docosahexaenoyl ethanolamide

Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.

Cat. No.

A16989

CAS No.

4449-55-2

Warangalone

Synonyms: Scandenolone

Warangalone is a prenylated isoflavone from the insecticidal plant Derris scandens that acts as a powerful inhibitor of protein kinase A.

Cat. No.

A17019

CAS No.

84468-24-6

HA-100 (C1)

Synonyms: HA100

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 μM, respectively).

Cat. No.

A17508

CAS No.

74536-44-0

Metadoxine

Metadoxine is a potent inhibitor of protein kinase A (PKA), specifically disrupting the PKA-cAMP response element binding protein (CREB) pathway. This compound is effective in blocking adipocyte differentiation, making it valuable for research into metabolic disorders and obesity-related pathways. Its ability to modulate PKA activity demonstrates potential applications in studying cellular signaling and metabolic regulation.

Cat. No.

A19279

CAS No.

121569-61-7

UCN-02

Synonyms: 7-epi-Hydroxystaurosporine

UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively.

Cat. No.

A20153

CAS No.

22242-96-2

Jaspamycin

Synonyms: 7-CN-7-C-Ino

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.