GSK1904529A

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IGF-1R inhibitor

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Catalog No. A10440

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GSK1904529A 5mg A10440-5

Regular Price: $80.00

Special Price: $68.00

GSK1904529A 10mg A10440-10

Regular Price: $138.00

Special Price: $117.30

GSK1904529A 25mg A10440-25

Regular Price: $200.00

Special Price: $170.00

GSK1904529A 50mg A10440-50

Regular Price: $348.00

Special Price: $295.80

GSK1904529A 10mM * 1mL in DMSO A10440-10mM-D

Regular Price: $229.00

Special Price: $194.65

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.

GSK1904529A

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Chemical Information

Catalog Num A10440
Actions Inhibitor
M. Wt 852
Formula C44H47F2N9O5S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1089283-49-7
Synonyms GSK-1904529A
SMILES code CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F
Chemical Name N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide

Biological Activity

Description
GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.
Targets
Target Value
Insulin ReceptorIC50: 25nM
IGF-1RIC50: 27nM
B-Raf(V600E)IC50: >2μM
SykIC50: 3.2μM
VEGFR2IC50: 3.2μM
IKK3IC50: 3.2μM
AuroraBIC50: 4μM
FynIC50: 6.3μM
RSK1IC50: 6.3μM
LCKIC50: 8μM
AuroraAIC50: >8μM
p38αIC50: 10μM
PKCεIC50: 10μM
PKCθIC50: >10μM
ActRIIBIC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
ALK5IC50: >10μM
CaMKK2IC50: >10μM
CDK2/CyclinAIC50: >10μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
JNK1IC50: >10μM
JNK2IC50: >10μM
JNK3IC50: >10μM
p70S6KIC50: >10μM
PAK1IC50: >10μM
PCTAIRE1IC50: >10μM
PDK-1IC50: >10μM
PI3KαIC50: >10μM
PI3KβIC50: >10μM
PI3KδIC50: >10μM
PI3KγIC50: >10μM
ROCK1IC50: >10μM
SIK2IC50: >10μM
Src1IC50: >10μM
YAK3IC50: >10μM
IKK1IC50: 13μM
IKK2IC50: 13μM
JAK3IC50: 13μM
JAK2IC50: >16μM
ZAP70IC50: >20μM
ASK1IC50: >25μM
ErbB4IC50: >25μM
GSK-3βIC50: >25μM
ITKIC50: >25μM
MAPKAPK2IC50: >25μM

Solubility

Solubility (25°C)* In vitro DMSO 124 mg/mL (145.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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