Hesperetin

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PDE4 inhibitor

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Catalog No. A10449

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Hesperetin 5mg A10449-5

Regular Price: $40.00

Special Price: $34.00

Hesperetin 10mg A10449-10

Regular Price: $50.00

Special Price: $42.50

Hesperetin 50mg A10449-50

Regular Price: $60.00

Special Price: $51.00

Hesperetin 100mg A10449-100

Regular Price: $80.00

Special Price: $68.00

Hesperetin 10mM * 1mL in DMSO A10449-10mM-D

Regular Price: $50.00

Special Price: $42.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.

Hesperetin

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Chemical Information

Catalog Num A10449
Actions Inhibitor
M. Wt 302.3
Formula C16H14O6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 520-33-2
Synonyms N/A
SMILES code COC1=C(C=C(C=C1)[[email protected]@H]2CC(=O)C3=C(C=C(C=C3O2)O)O)O
Chemical Name 2,​3-​dihydro-​5,​7-​dihydroxy-​2-​(3-​hydroxy-​4-​methoxyphenyl)-​4H-​1-​benzopyran-​4-​one

Biological Activity

Description
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
Targets
Histamine receptor TGF-β

Solubility

Solubility (25°C)* In vitro DMSO 60 mg/mL (198.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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