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INH1

Name: INH1
Brand: Adooq Bioscience
SKU: A13872
Availability: InStock

Cat. No. A13872 CAS 313553-47-8

Hec1 inhibitor

INH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores.

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Biological Activity

Target & Activity

Target	Activity	Value
Hec1

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HeLa	IC50	8.8 μM	Cytotoxicity against human HeLa cells after 4 days by XTT assay	[PMID: 19243176]
K562	IC50	11.7 μM	Cytotoxicity against human K562 cells after 4 days by XTT assay	[PMID: 19243176]
MDA-MB-231	IC50	0.839 μM	Inhibition of cell migration in human MDA-MB-231 cells assessed as total number of cells after 24 hrs by transwell migration assay	[PMID: 23526571]
MDA-MB-231	IC50	8.6 μM	Cytotoxicity against human MDA-MB-231 cells after 4 days XTT assay	[PMID: 19243176]
MDA-MB-468	IC50	10.5 μM	Cytotoxicity against human MDA-MB-468 cells after 4 days by XTT assay	[PMID: 19243176]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	313553-47-8
Applications	Hec1 inhibitor
Formula	C₁₈H₁₆N₂OS
Molecular Weight	308.4
Synonyms	Hec1/Nek2 Mitotic Pathway Inhibitor I
SMILES	CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	60 mg/mL (194.55 mM)
Water	Insoluble
Ethanol	60 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.