ITF2357 (Givinostat)

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HDAC inhibitor

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Catalog No. A10488

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ITF2357 5mg A10488-5
$90.00
ITF2357 10mg A10488-10
$160.00
ITF2357 50mg A10488-50
$450.00
ITF2357 100mg A10488-100
$750.00
ITF2357 (Givinostat) 10mM * 1mL in DMSO A10488-10mM-D
$145.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.

ITF2357 (Givinostat)

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Chemical Information

Catalog Num A10488
Actions Inhibitor
M. Wt 476.0
Formula C24H27N3O4.HCl.H2O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 732302-99-7
Synonyms Gavinostat
SMILES code CC[NH+](CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.[Cl-]
Chemical Name {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate

Biological Activity

Description
ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
Targets
HD1-B (Cell-free assay) HD2 (Cell-free assay) HD1-A (Cell-free assay)
7.5 nM10 nM16 nM

Solubility

Solubility (25°C) * In vitro DMSO 95 mg/mL (199.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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