HDAC1

Cat. No.

A10246

CAS No.

1012054-59-9

CUDC-101

CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

Cat. No.

A10764

CAS No.

382180-17-8

Pyroxamide (NSC 696085)

Synonyms: NSC-696085

Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent.

Cat. No.

A10852

CAS No.

156-54-7

Sodium butyrate

Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

Cat. No.

A10855

CAS No.

1069-66-5

Valproic acid sodium salt

Synonyms: Sodium Valproate

Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2.

Cat. No.

A11355

CAS No.

251456-60-7

M344

Synonyms: Histone Deacetylase Inhibitor III,MS344

M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation.

Cat. No.

A11361

CAS No.

926259-99-6

BG45

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).

Cat. No.

A11940

CAS No.

1316214-52-4

ACY-1215 (Rocilinostat)

Synonyms: ACY1215

ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.

Cat. No.

A11964

CAS No.

112522-64-2

Tacedinaline (CI994)

Synonyms: CI-994; Acetyldinaline; Goe 5549; G? 5549. PD 123654

CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.

Cat. No.

A12149

CAS No.

946150-57-8

Remetinostat

Synonyms: SHP-141

Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma.

Cat. No.

A12179

CAS No.

847460-34-8

CRA-026440

CRA-026440 is a potent, broad-spectrum HDAC inhibitor.

Cat. No.

A12253

CAS No.

934828-12-3

Zabadinostat (CXD101)

Synonyms: CXD 101

CXD101 is a class I-selective HDAC inhibitor (HDAC1 (IC50, 63 nM), HDAC2 (IC50, 570 nM), HDAC3 (IC50, 550 nM). CXD101 has no activity against HDAC class II.

Cat. No.

A12511

CAS No.

849234-64-6

BRD-6929

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927.

Cat. No.

A12556

CAS No.

864814-88-0

Resminostat

Synonyms: 4SC-201; RAS2410

Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.

Cat. No.

A12722

CAS No.

287383-59-9

Scriptaid

Scriptaid is an HDAC inhibitor (histone deacetylase).

Cat. No.

A12745

CAS No.

183506-66-3

Apicidin

Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.

Cat. No.

A13139

CAS No.

1215493-56-3

RG2833 (RGFP109)

Synonyms: RGFP109

RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3.

Cat. No.

A13462

CAS No.

2271413-06-8

HDACs/mTOR Inhibitor 1

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies.

Cat. No.

A14341

CAS No.

1418033-25-6

LMK-235

LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.

Cat. No.

A14354

CAS No.

910462-43-0

Domatinostat (4SC-202)

Synonyms: 4SC-202

4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.

Cat. No.

A14418

CAS No.

1428535-92-5

ST7612AA1

ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity.

Cat. No.

A15220

CAS No.

1187075-34-8

Resminostat hydrochloride

Synonyms: RAS2410 hydrochloride; 4SC-201 hydrochloride

Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.

Cat. No.

A15354

CAS No.

940943-37-3

KD 5170

KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.

Cat. No.

A15355

CAS No.

848354-66-5

PTACH (NCH 51)

Synonyms: NCH 51

NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.

Cat. No.

A15357

CAS No.

937039-45-7

TC-H 106

Synonyms: Pimelic Diphenylamide 106; Histone Deacetylase Inhibitor VII

TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases).

Cat. No.

A15781

CAS No.

537672-41-6

UF010

UF010 is a potent and selective HDAC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.