Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| Shh Light II | IC50 | 30 nM | Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assay | [PMID: 19309080] |
Fig. 1 · Structure
Documents & Downloads
JK 184
Cat. No.
A12925
CAS
315703-52-7
Hedgehog inhibitor
JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 315703-52-7 |
| Applications | Hedgehog inhibitor |
| Formula | C19H18N4OS |
| Molecular Weight | 350.44 |
| SMILES | CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 69 mg/mL (196.89 mM) |
| Water | Insoluble |
| Ethanol | 14 mg/mL (39.94 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.