Target & Activity
| Target | Activity | Value |
|---|---|---|
| RAAS |
Fig. 1 · Structure
Documents & Downloads
Sacubitril/Valsartan (LCZ696)
Cat. No.
A14206
CAS
936623-90-4
angiotensin receptor-neprilysin inhibitor
LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 936623-90-4 |
| Applications | angiotensin receptor-neprilysin inhibitor |
| Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
| Molecular Weight | 915.98 |
| Synonyms | LCZ696 |
| SMILES | CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O.CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.O.O.O.[Na+].[Na+].[Na+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 26 mg/mL (28.38 mM) |
| Water | Warmed: 88 mg/mL (96.07 mM) |
| Ethanol | Warmed: 8 mg/mL |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.