LY2811376

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BACE1 inhibitor

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Catalog No. A11776

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LY2811376 5mg A11776-5

Regular Price: $90.00

Special Price: $76.50

LY2811376 10mg A11776-10

Regular Price: $160.00

Special Price: $136.00

LY2811376 50mg A11776-50

Regular Price: $500.00

Special Price: $425.00

LY2811376 100mg A11776-100

Regular Price: $850.00

Special Price: $722.50

LY2811376 10mM * 1mL in DMSO A11776-10mM-D

Regular Price: $117.00

Special Price: $99.45

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.

LY2811376

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Chemical Information

Catalog Num A11776
Actions Inhibitor
M. Wt 320.4
Formula C15H14F2N4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1194044-20-6
Synonyms LY 2811376, LY-2811376
SMILES code C[[email protected]]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
Chemical Name (S)-4-(2,4-difluoro-5-pyrimidin-5-yl-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]thiazin-2-ylamine

Biological Activity

Description
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
Targets
BACE1
239 nM-249 nM~300 nM(EC50)

Solubility

Solubility (25°C) * In vitro DMSO 16 mg/mL (49.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199.77 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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