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IGF-1R inhibitor
In Stock
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| Target | Activity | Value |
|---|---|---|
| IGF-1R | 0.17 μM |
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| HeLa | IC50 | 3.05 μM | Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay | [PMID: 29624387] |
| Sf21 | IC50 | 78 nM | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay | [PMID: 17689078] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 475488-23-4 |
| Applications | IGF-1R inhibitor |
| Formula | C28H31N5O |
| Molecular Weight | 453.6 |
| Synonyms | ADW742; GSK 552602A |
| SMILES | NC1=NC=NC2=C1C(C3=CC=CC(OCC4=CC=CC=C4)=C3)=CN2[C@@H]5C[C@@H](CN6CCCC6)C5 |
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 9 mg/mL (19.84 mM) |
| Water | Insoluble |
| Ethanol | 3 mg/mL (6.61 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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