NVP-BHG712

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EphB4 inhibitor

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Catalog No. A10661

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NVP-BHG712 5mg A10661-5

Regular Price: $80.00

Special Price: $68.00

NVP-BHG712 10mg A10661-10

Regular Price: $150.00

Special Price: $127.50

NVP-BHG712 50mg A10661-50

Regular Price: $700.00

Special Price: $595.00

NVP-BHG712 100mg A10661-100

Regular Price: $1,200.00

Special Price: $1,020.00

NVP-BHG712 10mM * 1mL in DMSO A10661-10mM-D

Regular Price: $140.00

Special Price: $119.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

NVP-BHG712

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Chemical Information

Catalog Num A10661
Actions Inhibitor
M. Wt 503.5
Formula C26H20F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 940310-85-0
Synonyms NVPBHG712
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
Chemical Name 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide trifluoroacetate

Biological Activity

Description
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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