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JAK inhibitor
NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.
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| Target | Activity | Value |
|---|---|---|
| JAK2 JH1 | IC50 | 0.48 nM |
| JAK2(V617F) | IC50 | 0.56 nM |
| FL JAK2 wt | IC50 | 0.58 nM |
| TYK2 JH1 | IC50 | 18.68 nM |
| JAK1 JH1 | IC50 | 31.68 nM |
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| SET-2 | GI50 | 88 nM | Growth inhibition of human SET2 cells expressing JAK2V617F mutant after 72 hrs by colorimetric WST1 assay | [PMID: 20231096] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1092499-93-8 |
| Applications | JAK inhibitor |
| Formula | C27H28F2N6O |
| Molecular Weight | 490.55 |
| SMILES | FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1 |
No reported solubility data are available for this product.
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
