NVP-BSK805 dihydrochloride

Catalog No.: A21406

JAK2 inhibitor

NVP-BSK805 dihydrochloride

NVP-BSK805 dihydrochloride Chemical Structure

CAS NO. 1942919-79-0

NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

Availability: In stock

Package Price Qty
5 mg
$151.00
10 mg
$260.00
50 mg
$773.00
100 mg
$1,546.00
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Biological Activity

NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
In vitro (25°C) DMSO 104 mg/mL (184.57 mM)
Water 3 mg/mL (5.32 mM)
Ethanol 14 mg/mL (24.85 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.75 mL 88.74 mL 177.47 mL
0.5 mM 3.55 mL 17.75 mL 35.49 mL
1 mM 1.77 mL 8.87 mL 17.75 mL
5 mM 0.35 mL 1.77 mL 3.55 mL

*The above data is based on the productmolecular weight 563.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21406
Actions Inhibitor
CAS No. 1942919-79-0
Formula C27H30Cl2F2N6O
M. Wt 563.47
Solubility DMSO
Purity >98%
Synonyms BSK805 dihydrochloride, BSK 805, BSK-805
SMILES FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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