NVP-BSK805 dihydrochloride

Catalog No.: A21406
JAK2 inhibitor
NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
Grouped product items
Product Name Price Stock Qty
NVP-BSK805 dihydrochloride 5mg
$151.00
In stock
NVP-BSK805 dihydrochloride 10mg
$260.00
In stock
NVP-BSK805 dihydrochloride 50mg
$773.00
In stock
NVP-BSK805 dihydrochloride 100mg
$1,546.00
In stock
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Biological Activity
Discription NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
Targets
Target Value
Product Information
Catalog Num A21406
Formula C27H30Cl2F2N6O
Molecular Weight 563.47
CAS Number 1942919-79-0
SMILES FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl
Synonyms BSK805 dihydrochloride, BSK 805, BSK-805
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 104 mg/mL (184.57 mM)
Water 3 mg/mL (5.32 mM)
Ethanol 14 mg/mL (24.85 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.75 mL 88.74 mL 177.47 mL
0.5 mM 3.55 mL 17.75 mL 35.49 mL
1 mM 1.77 mL 8.87 mL 17.75 mL
5 mM 0.35 mL 1.77 mL 3.55 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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