OSI-906

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IGF-1R inhibitor

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Catalog No. A11053

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
OSI-906 5mg A11053-5

Regular Price: $50.00

Special Price: $42.50

OSI-906 10mg A11053-10

Regular Price: $70.00

Special Price: $59.50

OSI-906 50mg A11053-50

Regular Price: $150.00

Special Price: $127.50

OSI-906 100mg A11053-100

Regular Price: $210.00

Special Price: $178.50

OSI-906 10mM * 1mL in DMSO A11053-10mM-D

Regular Price: $50.00

Special Price: $42.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

OSI-906

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Chemical Information

Catalog Num A11053
Actions Inhibitor
M. Wt 421.5
Formula C26H23N5O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 867160-71-2
Synonyms OSI906
SMILES code CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Chemical Name cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol

Biological Activity

Description
OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
Targets
Target Value
IGF-1RIC50: 35nM
Insulin ReceptorIC50: 75nM
IRRIC50: 75nM
AblIC50: >10μM
ALKIC50: >10μM
BTKIC50: >10μM
EGFRIC50: >10μM
EphA1IC50: >10μM
EphB1IC50: >10μM
FESIC50: >10μM
FGFR1IC50: >10μM
FGFR2IC50: >10μM
FynIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
ROCK1IC50: >10μM
IRAK4IC50: >10μM
JAK2IC50: >10μM
KDRIC50: >10μM
LCKIC50: >10μM
LynAIC50: >10μM
LynBIC50: >10μM
MetIC50: >10μM
TrkAIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
FAKIC50: >10μM
BRKIC50: >10μM
RETIC50: >10μM
Pim1IC50: >10μM
CDK1IC50: >10μM
DYRK2IC50: >10μM
SrcIC50: >10μM
TekIC50: >10μM
MEK1IC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
PDK-1IC50: >10μM
PLK1IC50: >10μM
p38αIC50: >10μM
ERK1IC50: >10μM
GSK-3αIC50: >10μM
p70S6KIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 84 mg/mL (199.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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