P 22077

USP7 inhibitor

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Catalog No. A12933

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
P 22077 10mg A12933-10
$70.00
P 22077 25mg A12933-25
$140.00
P 22077 50mg A12933-50
$220.00
P 22077 100mg A12933-100
$380.00
P 22077 10mM * 1mL in DMSO A12933-10mM-D
$97.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 ?M) and the closely related deubiquitinase (DUB) USP47.

P 22077

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Chemical Information

Catalog Num A12933
Actions Inhibitor
M. Wt 315.32
Formula C12H7F2NO3S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1247819-59-5
Synonyms P22077
SMILES code CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]
Chemical Name 1-[5-[(2,4-Difluorophenyl)thio]-4-n?itro-2-thienyl]-ethanone

Biological Activity

Description
P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 ?M) and the closely related deubiquitinase (DUB) USP47.
Targets
Target Value
USP7EC508.6μM
USP47EC508.74μM
USP2coreEC50>50μM
USP4EC50>50μM
USP5EC50>50μM
USP8EC50>50μM
USP15EC50>50μM
USP20EC50>50μM
USP28EC50>50μM
JOSD2EC50>50μM
UCH-L1EC50>50μM
UCH-L3EC50>50μM
UCH-L5EC50>50μM
DEN1EC50>50μM
PlproEC50>50μM
SENP6coreEC50>50μM
PLA2EC50>50μM
Calpain1EC50>50μM
CT-LEC50>50μM
CathepsinDEC50>50μM
MMP13EC50>50μM
TrypsinEC50>50μM

Solubility

Solubility (25°C)* In vitro DMSO 63 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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