P505-15 (PRT062607, BIIB057)

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Syk inhibitor

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Catalog No. A11952

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
P505-15 5mg A11952-5

Regular Price: $100.00

Special Price: $80.00

P505-15 10mg A11952-10

Regular Price: $180.00

Special Price: $144.00

P505-15 25mg A11952-25

Regular Price: $350.00

Special Price: $280.00

P505-15 50mg A11952-50

Regular Price: $600.00

Special Price: $480.00

P505-15 10mM * 1mL in DMSO A11952-10mM-D

Regular Price: $138.00

Special Price: $110.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

P505-15 (PRT062607, BIIB057)

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Chemical Information

Catalog Num A11952
Actions Inhibitor
M. Wt 393.45
Formula C19H23N9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1370261-96-3
Synonyms P50515, PRT062607
SMILES code CC(=O)O.C1CC[[email protected]]([[email protected]](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N
Chemical Name 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2S)-2-aminocyclohexylamino) pyrimidine-5-carboxamide

Biological Activity

Description
P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

Solubility

Solubility (25°C) * In vitro DMSO 86 mg/mL (200.04 mM)
Water 86 mg/mL (200.04 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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