P505-15 (PRT062607, BIIB057)

P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
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Product Name Price Stock Qty
P505-15 5mg
$100.00
In stock
P505-15 10mg
$180.00
In stock
P505-15 25mg
$350.00
In stock
P505-15 50mg
$600.00
In stock
P505-15 10mM * 1mL in DMSO
$138.00
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Adooq Products cited in reputable paper
Adooq's P505-15 (PRT062607, BIIB057) has been cited by 1 publications
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Biological Activity
    Discription P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
    Product Information
    Catalog Num A11952
    Formula C19H23N9O
    Molecular Weight 393.45
    CAS Number 1370261-96-3
    SMILES C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)N4N=CC=N4)C(=O)N
    Synonyms P50515, PRT062607
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 85 mg/mL (197.71 mM)
    Water 85 mg/mL (197.71 mM)
    Ethanol Insoluble
    In vivo Saline 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.42 mL 127.08 mL 254.16 mL
    0.5 mM 5.08 mL 25.42 mL 50.83 mL
    1 mM 2.54 mL 12.71 mL 25.42 mL
    5 mM 0.51 mL 2.54 mL 5.08 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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