Syk

Cat. No.

A11926

CAS No.

901119-35-5

Fostamatinib (R788)

Synonyms: R-788

R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.

Cat. No.

A11320

CAS No.

732983-37-8

BAY 61-3606

BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

Cat. No.

A10769

CAS No.

841290-81-1

R406 besylate

Synonyms: R-406

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.

Cat. No.

A11952

CAS No.

1370261-96-3

P505-15 (PRT062607, BIIB057)

Synonyms: PRT062607; BIIB057

P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

Cat. No.

A10770

CAS No.

841290-80-0

Tamatinib (R406)

Synonyms: R-406

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.

Cat. No.

A10771

CAS No.

1025687-58-4

Fostamatinib disodium (R935788, R788)

Synonyms: R-935788; R788

R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.

Cat. No.

A12162

CAS No.

10083-24-6

Piceatannol

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression.

Cat. No.

A12731

CAS No.

1370261-97-4

PRT062607 HCL

Synonyms: P505-15; PRT2607; PRT-062607; BIIB057

PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

Cat. No.

A12959

CAS No.

1800046-95-0

Lanraplenib

Synonyms: GS-9876

Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.

Cat. No.

A13884

CAS No.

1229208-44-9

Entospletinib (GS-9973)

Synonyms: GS9973

GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity.

Cat. No.

A14147

CAS No.

1198300-79-6

Cerdulatinib (PRT 062070)

Synonyms: PRT2070; PRT-062070

PRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types.

Cat. No.

A14161

CAS No.

575474-82-7

R112

R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested.

Cat. No.

A15017

CAS No.

648903-57-5

BAY 61-3606 dihydrochloride

Synonyms: BAY61-3606

BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase.

Cat. No.

A15524

CAS No.

1194961-19-7

PRT-060318

Synonyms: PRT318; P142–76.

PRT-060318 is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment.

Cat. No.

A16240

CAS No.

1485-00-3

MNS

Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.

Cat. No.

A16686

CAS No.

1446790-62-0

RO9021

RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM.

Cat. No.

A19883

CAS No.

1425381-60-7

Gusacitinib

Synonyms: ASN-002

Gusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM.

Cat. No.

A20450

CAS No.

1312691-33-0

TAK-659

TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively.

Cat. No.

A21873

CAS No.

914295-16-2

Fostamatinib disodium hexahydrate

Synonyms: R788 (disodium hexahydrate); R 788

Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

Cat. No.

A21885

CAS No.

1952251-28-3

TAK-659 hydrochloride

TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.

Cat. No.

A22305

CAS No.

2254693-15-5

SRX3207

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

Cat. No.

A24148

CAS No.

2341796-81-2

GSK143 dihydrochloride

GSK143 dihydrochloride is an orally active and highly selective inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC₅₀ of 7.5. It also inhibits phosphorylated ERK (pErk) with a pIC₅₀ of 7.1, indicating its ability to modulate downstream signaling pathways involved in immune responses. In preclinical models, GSK143 dihydrochloride effectively reduces inflammation and prevents the recruitment of immune cells to the intestinal muscularis, highlighting its potential as a therapeutic agent for inflammatory diseases, particularly those involving the gastrointestinal tract.

Cat. No.

A29528

CAS No.

1965323-05-0

Syk Inhibitor II dihydrochloride dihydrate

Syk Inhibitor II dihydrochloride dihydrate is a selective and ATP-competitive inhibitor of Syk with an IC50 of 41 nM. This compound effectively inhibits 5-HT release from RBL cells, demonstrating an IC50 of 460 nM. With reduced potency against other kinases, it holds potential for applications in treating allergic responses and exploring the role of Syk in various immunological processes.

Cat. No.

A29854

CAS No.

2490508-82-0

Syk Inhibitor II hydrochloride

Syk Inhibitor II hydrochloride is a highly selective ATP-competitive inhibitor of Syk kinase, exhibiting an IC50 of 41 nM. This compound effectively inhibits serotonin release from RBL cells, with an IC50 of 460 nM. Syk Inhibitor II hydrochloride demonstrates reduced potency against other kinases, making it a valuable tool for investigating Syk-mediated signaling pathways and exploring its anti-allergic properties in research applications.

Cat. No.

A30408

CAS No.

1615197-10-8

BAY 61-3606 hydrochloride

BAY 61-3606 hydrochloride is a highly selective Syk inhibitor that acts in an ATP-competitive manner with a Ki of 7.5 nM and an IC50 of 10 nM. It effectively reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and significantly decreases Syk phosphorylation in K-rn cell lysates. Additionally, BAY 61-3606 hydrochloride enhances TRAIL-induced apoptosis in breast cancer cells by downregulating Mcl-1, making it a valuable tool for investigating Syk-related pathways in cancer research.