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Pepstatin A

Name: Pepstatin A
Brand: Adooq Bioscience
SKU: A14262
Availability: InStock

Cat. No. A14262 CAS 26305-03-3

aspartic protease inhibitor

Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.

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Biological Activity

Target & Activity

Target	Activity	Value
aspartic protease

Cellular Effect

Cell Line	Activity	Value	Description	Reference
H9	EC50	51.8 μM	Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique	[PMID: 11430019]
MCF7	IC50	5 nM	Inhibition of cathepsin D in human MCF7 cells by fluorescence assay	[PMID: 19715320]
MCF7	IC50	5 nM	Inhibition of cathepsin E in human MCF7 cells by fluorescence assay	[PMID: 19715320]
MCF7	IC50	5 μM	Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay	[PMID: 19715320]
MCF7	IC50	5 μM	Inhibition of cathepsin E in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay	[PMID: 19715320]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	26305-03-3
Applications	aspartic protease inhibitor
Formula	C₃₄H₆₃N₅O₉
Molecular Weight	685.89
Synonyms	Pepstation-A
SMILES	CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	51 mg/mL (74.35 mM)
Water	Insoluble
Ethanol	Warmed: 1 mg/mL (1.45 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.