Ramelteon (TAK-375)

Catalog No.: A10777
MT1/MT2-Receptor Agonist
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ?? 8.55 pM)and MT2 (20.1 ?? 9.25 pM)receptors and selectivity over the MT3 receptor.
Grouped product items
Product Name Price Stock Qty
Ramelteon 5mg
$68.00
In stock
Ramelteon 10mg
$116.00
In stock
Ramelteon 25mg
$204.00
In stock
Ramelteon 50mg
$340.00
In stock
Ramelteon (TAK-375) 10mM * 1mL in DMSO
$106.00
In stock
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Biological Activity
Discription Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ?? 8.55 pM)and MT2 (20.1 ?? 9.25 pM)receptors and selectivity over the MT3 receptor.
Targets
Target Value
Product Information
Catalog Num A10777
Formula C16H21NO2
Molecular Weight 259.3
CAS Number 196597-26-9
SMILES CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3
Synonyms Rozerem, TAK-375, TAK375
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 47 mg/mL (181.22 mM)
Water Insoluble
Ethanol 47 mg/mL (181.22 mM)
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.57 mL 192.83 mL 385.65 mL
0.5 mM 7.71 mL 38.57 mL 77.13 mL
1 mM 3.86 mL 19.28 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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    C2

    V2

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