Ramelteon (TAK-375)

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MT1/MT2-Receptor Agonist

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Catalog No. A10777

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ramelteon 5mg A10777-5

Regular Price: $90.00

Special Price: $76.50

Ramelteon 10mg A10777-10

Regular Price: $120.00

Special Price: $102.00

Ramelteon 25mg A10777-25

Regular Price: $200.00

Special Price: $170.00

Ramelteon 50mg A10777-50

Regular Price: $260.00

Special Price: $221.00

Ramelteon (TAK-375) 10mM * 1mL in DMSO A10777-10mM-D

Regular Price: $106.00

Special Price: $90.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.

Ramelteon (TAK-375)

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Chemical Information

Catalog Num A10777
Actions Agonist
M. Wt 259.3
Formula C16H21NO2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 196597-26-9
Synonyms Rozerem, TAK-375, TAK375
SMILES code CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3
Chemical Name (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b] furan-8-yl)ethyl]propionamide

Biological Activity

Description
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor.
Targets
MT1 receptor MT receptor (chicken) MT2 receptor
14 pM(Ki)23.1 pM(Ki)112 pM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 52 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 52 mg/mL (200.5 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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