RO4929097

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Gamma-secretase inhibitor

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Catalog No. A10802

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
RO4929097 5mg A10802-5

Regular Price: $100.00

Special Price: $80.00

RO4929097 10mg A10802-10

Regular Price: $180.00

Special Price: $144.00

RO4929097 50mg A10802-50

Regular Price: $560.00

Special Price: $448.00

RO4929097 200mg A10802-200

Regular Price: $1,380.00

Special Price: $1,104.00

RO4929097 10mM * 1mL in DMSO A10802-10mM-D

Regular Price: $153.00

Special Price: $122.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.

RO4929097

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Chemical Information

Catalog Num A10802
Actions Inhibitor
M. Wt 469.4
Formula C22H20F5N3O3
Solubility DMSO>94mg/mL Water<1mg/mL Ethanol>16mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 847925-91-1
Synonyms N/A
SMILES code CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
Chemical Name N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide

Biological Activity

Description
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
Targets
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM

Solubility

Solubility (25°C) * In vitro DMSO 94 mg/mL (200.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (34.08 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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