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RO4987655

Name: RO4987655
Brand: Adooq Bioscience
SKU: A13272
Availability: InStock

Cat. No. A13272 CAS 874101-00-5

MEK1 inhibitor

RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity.

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Biological Activity

Target & Activity

Target	Activity	Value
MEK1	IC50	5.2 nM
MEK2	IC50	5.2 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
C32	IC50	8.4 nM	Cytotoxicity against human C32 cells expressing b-Raf V600E mutant after 4 days	[PMID: 21316218]
COLO 205	IC50	0.86 nM	Cytotoxicity against human COLO205 cells expressing b-Raf V600E mutant after 4 days	[PMID: 21316218]
HT-29	IC50	1.7 nM	Cytotoxicity against human HT-29 cells expressing b-Raf V600E mutant after 4 days	[PMID: 21316218]
MIA PaCa-2	IC50	3.3 nM	Cytotoxicity against human MIAPaCa2 cells expressing Kras G12C mutant after 4 days	[PMID: 21316218]
QG-56	IC50	9.5 nM	Cytotoxicity against human QG56 cells expressing Hras Q61L mutant after 4 days	[PMID: 21316218]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	874101-00-5
Applications	MEK1 inhibitor
Formula	C₂₀H₁₉F₃IN₃O₅
Molecular Weight	565.28
SMILES	C1CC(=O)N(OC1)CC2=C(C(=C(C(=C2)C(=O)NOCCO)NC3=C(C=C(C=C3)I)F)F)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.