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|Storage||at -20°C 3 years Powder|
|SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells|
|Solubility (25°C) *||In vitro||DMSO||68 mg/mL (198 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||68 mg/mL (198 mM)|
|In vivo||30% propylene glycol, 5% Tween 80, 65% D5W||20 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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