SB 525334

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ALK Inhibitor

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Catalog No. A10827

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 525334 5mg A10827-5

Regular Price: $50.00

Special Price: $42.50

SB 525334 10mg A10827-10

Regular Price: $90.00

Special Price: $76.50

SB 525334 50mg A10827-50

Regular Price: $300.00

Special Price: $255.00

SB 525334 100mg A10827-100

Regular Price: $500.00

Special Price: $425.00

SB 525334 10mM * 1mL in DMSO A10827-10mM-D

Regular Price: $60.00

Special Price: $51.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells

SB 525334

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Chemical Information

Catalog Num A10827
Actions Inhibitor
M. Wt 343.4
Formula C21H21N5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 356559-20-1
Synonyms SB-525334, SB525334
SMILES code CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
Chemical Name No

Biological Activity

Description
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
Targets
TGFβR1(ALK5) (Cell-free assay)
14.3 nM

Solubility

Solubility (25°C) * In vitro DMSO 68 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 68 mg/mL (198 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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