We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Fig. 1 · Structure
Cat. No.
A13036
CAS No.
147817-50-3
Formula
C30H31FN2O
Mol. Weight
454.58

Documents & Downloads

Siramesine

Cat. No. A13036 CAS 147817-50-3

Sigma-2 receptor agonist

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation.

In Stock

Notify me when the price drops

For laboratory research use only. We do not sell to patients.

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
C6 EC50 43.1 μM Antiproliferative activity against rat C6 cells assessed as reduction in cell viability after 24 hrs by MTT assay 10.1039/C5MD00079C
DU-145 EC50 13.9 μM Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay 10.1039/C5MD00079C
EMT6 EC50 14.9 μM Antagonist activity at sigma-2 receptor in mouse EMT6 cells assessed as inhibition of cell proliferation after 24 hrs by MTS assay [PMID: 24821398]
EMT6 EC50 5.3 μM Antagonist activity at sigma-2 receptor in mouse EMT6 cells assessed as inhibition of cell proliferation after 48 hrs by MTS assay [PMID: 24821398]
MCF7 EC50 12.3 μM Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay 10.1039/C5MD00079C
MCF7 IC50 13 μM Cytotoxicity against ER/PR-positive HER2-negative human MCF7 cells harbouring p53 R175H mutant assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay [PMID: 35724925]
MCF7 EC50 23.6 μM Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay 10.1039/C5MD00079C
SK-BR-3 IC50 14 μM Cytotoxicity against ER/PR-negative HER2-positive human SK-BR-3 cells harbouring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay [PMID: 35724925]

Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 147817-50-3
Applications Sigma-2 receptor agonist
Formula C30H31FN2O
Molecular Weight 454.58
Synonyms Lu 28-179
SMILES
C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Added to your cart

View Cart Checkout
Loading...