SP600125 ON SALE JNK inhibitor

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Catalog No. A10860

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SP600125 10mg A10860-10

Regular Price: $40.00

Special Price: $34.00

SP600125 25mg A10860-25

Regular Price: $80.00

Special Price: $68.00

SP600125 50mg A10860-50

Regular Price: $150.00

Special Price: $127.50

SP600125 200mg A10860-200

Regular Price: $500.00

Special Price: $425.00

SP600125 10mM * 1mL in DMSO A10860-10mM-D

Regular Price: $68.00

Special Price: $57.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.

SP600125

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Chemical Information

Catalog Num A10860
Actions Inhibitor
M. Wt 220.2
Formula C14H8N2O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 129-56-6
Synonyms N/A
SMILES code C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
Chemical Name 1,9-Pyrazoloanthrone

Biological Activity

Description
SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
Targets
Target Value
JNK1IC50: 40nM
JNK2IC50: 40nM
AuroraAIC50: 60nM
TrkAIC50: 70nM
JNK3IC50: 90nM
FLT3IC50: 90nM
MKK4IC50: 0.4μM
MKK6IC50: 1.0μM
PKBIC50: 1.0μM
MKK3IC50: 1.5μM
PKCαIC50: 1.5μM
p56LCKIC50: 4.3μM
MKK7IC50: 5.1μM
MEKK1IC50: >10μM
ERK2IC50: >10μM
p38βIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
PKCθIC50: >10μM
Chk1IC50: >10μM
EGFIC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 44 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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