Target & Activity
| Target | Activity | Value |
|---|---|---|
| PDGFRβ | Ki | 5 nM |
| Flk-1 | Ki | 6 nM |
Fig. 1 · Structure
Documents & Downloads
Toceranib (PHA 291639, SU 11654)
Cat. No.
A11581
CAS
356068-94-5
c-Kit, PDGFR, VEGFR inhibitor
Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 356068-94-5 |
| Applications | c-Kit, PDGFR, VEGFR inhibitor |
| Formula | C22H25FN4O2 |
| Molecular Weight | 396.46 |
| Synonyms | PHA 291639; SU 11654 |
| SMILES | CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)/C=C\3/C4=C(C=CC(=C4)F)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
1 publication citing this product
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Masaya Igase, .et al. , Can J Vet Res, 2016, Jan; 80(1): 21-31 PMID: 26733729