Torin 2

mTOR inhibitor

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Catalog No. A11586

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Torin 2 10mg A11586-10
$110.00
Torin 2 25mg A11586-25
$200.00
Torin 2 50mg A11586-50
$330.00
Torin 2 100mg A11586-100
$490.00
Torin 2 10mM * 1mL in DMSO A11586-10mM-D
$111.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).

Torin 2

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Chemical Information

Catalog Num A11586
Actions Inhibitor
M. Wt 432.4
Formula C24H15F3N4O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1223001-51-1
Synonyms Torin2
SMILES code C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
Chemical Name 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one

Biological Activity

Description
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
Targets
mTOR (p53?/? MEFs) ATM (PC3 cells) ATR (PC3 cells) DNA-PK (PC3 cells)
0.25 nM28 nM(EC50)35 nM(EC50)118 nM(EC50)

Solubility

Solubility (25°C) * In vitro DMSO 20 mg/mL (46.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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