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Fig. 1 · Structure
Cat. No.
A13210
CAS No.
35943-35-2
Formula
C13H16N6O4
Mol. Weight
320.31

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Triciribine

Cat. No. A13210 CAS 35943-35-2

AKT Inhibitor

Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt.

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Biological Activity

Target & Activity

Target Activity Value
HIV-1 (CEM-SS, H9, H9IIIB, U1 cells) 20 nM
Akt (PC3 cells) 130 nM

Cellular Effect

Cell Line Activity Value Description Reference
184B5 GI50 16.96 μM Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay [PMID: 18691894]
184B5 GI50 34 μM Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay [PMID: 18691894]
184B5 GI50 40 μM Cytotoxicity against human 184B5 cells by SRB assay [PMID: 18691894]
AA5 IC50 < 0.17 μM Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 3.13 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay [PMID: 20086149]
AA5 IC50 < 0.17 μM Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay [PMID: 20086149]
AA5 IC50 < 0.17 μM Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 0.78 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay [PMID: 20086149]
AA5 IC50 > 53.1 μM Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 3.13 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA [PMID: 20086149]
AA5 IC50 > 53.1 μM Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA [PMID: 20086149]
AA5 IC50 > 53.1 μM Antiviral activity against Human immunodeficiency virus 1 3B infected in AA5 cells infected with 0.78 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA [PMID: 20086149]
AA5 IC50 > 53.1 μM Cytotoxicity against human AA5 cells by MTS assay [PMID: 20086149]
ACH-2 cell line CC50 0.01 μM Cytotoxicity against human ACH2 cells infected with latent Human immunodeficiency virus 1 by MTS assay [PMID: 20086149]
ACH-2 cell line CC50 0.01 μM Cytotoxicity against human ACH2 cells infected with latent Human immunodeficiency virus 1 by MTS assay in presence of tumor necrosis factor alpha [PMID: 20086149]
ACH-2 cell line IC50 0.15 μM Antiviral activity against 5 x 10'3 cells/well Human immunodeficiency virus 1 infected in human ACH2 cells assessed as inhibition of viral Reverse transcriptase after 3 days by [3H]TTP incorporation assay in presence of 5 ng/ml tumor necrosis factor alpha [PMID: 20086149]
BSC-1 IC50 23 μM Antiviral activity was tested using an enzyme-linked immunosorbent assay (ELISA) to detect HSV-1 (herpes simplex virus type 1) using BSC-1 cells [PMID: 10882371]
BSC-1 IC50 23 μM Antiviral activity against HSV-1 was determined using BSC-1 cells by an enzyme-linked immunosorbent assay (ELISA) [PMID: 10882373]
CEM-SS IC50 < 0.01 μM Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM-SS cells infected with 0.78 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA [PMID: 20086149]
CEM-SS IC50 > 10 μM Antiviral activity against Human immunodeficiency virus 1 harboring plasmid TAK-1 infected in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay [PMID: 20086149]
CEM-SS IC50 > 3.13 μM Cytotoxicity against human CEM-SS cells by MTS assay [PMID: 20086149]
CEM-SS IC50 > 30 μM Antiviral activity against Human immunodeficiency virus 1 A12 harboring Tyr127His, Asp174Asn and Arg178Lys mutations in nef protein infecting in CEM-SS cells assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay [PMID: 20086149]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 35943-35-2
Applications AKT Inhibitor
Formula C13H16N6O4
Molecular Weight 320.31
Synonyms NSC 154020; TCN; API-2
SMILES
CN1C2=NC=NC3=C2C(=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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