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Vinblastine sulfate

Name: Vinblastine sulfate
Brand: Adooq Bioscience
SKU: A13661
Availability: InStock

Cat. No. A13661 CAS 143-67-9

microtubule dynamics inhibitor

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

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Biological Activity

Cellular Effect

Cell Line	Activity	Value	Description	Reference
A-375	IC50	7.2 μM	Cytotoxicity against human A375 cells after 48 hrs by SRB assay	[PMID: 19467877]
A549	IC50	2.36 μM	Antiproliferative activity against human A549 cells after 48 hrs by MTS assay	[PMID: 22546674]
A549	IC50	67.3 μM	Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 19467877]
ACHN	IC50	22.7 μM	Cytotoxicity against human ACHN cells after 48 hrs by SRB assay	[PMID: 19467877]
BXPC-3	IC50	1.13 μM	Antiproliferative activity against human BxPC3 cells after 48 hrs by MTS assay	[PMID: 22546674]
C32	IC50	3 μM	Cytotoxicity against human C32 cells after 48 hrs by SRB assay	[PMID: 19467877]
Caco-2	IC50	69 μM	Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay	[PMID: 19467877]
COR-L23	IC50	45.5 μM	Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay	[PMID: 19467877]
DU-145	IC50	4.25 μM	Antiproliferative activity against human DU145 cells after 48 hrs by MTS assay	[PMID: 22546674]
HepG2	IC50	0.019 μM	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708010]
HepG2	IC50	0.056 μM	Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23708010]
HepG2	IC50	0.16 μM	Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay	[PMID: 22546674]
HT-29	IC50	0.55 μM	Cytotoxicity against human HT-29 cells after 48 hrs by MTS assay	[PMID: 21920762]
HT-29	IC50	11.18 μM	Antiproliferative activity against human HT-29 cells after 48 hrs by MTS assay	[PMID: 22546674]
K562	IC50	0.001 μM	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer	[PMID: 21705223]
K562	IC50	0.001 μM	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis	[PMID: 21563750]
K562	IC50	0.001 μM	Cell growth inhibition of human K562 cells after 48 hrs	[PMID: 20546980]
K562	IC50	0.001 μM	Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 20537765]
K562	IC50	0.001 μM	Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 19220018]
K562	IC50	0.001 μM	Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 17973361]
K562	IC50	0.016 μM	Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	143-67-9
Applications	microtubule dynamics inhibitor
Formula	C₄₆H₅₈N₄O₉.H₂SO₄
Molecular Weight	909.05
Synonyms	Vincaleukoblastine sulfate salt
SMILES	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	93 mg/mL (102.3 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Vinblastine sulfate

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DMSO Solution