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Fig. 1 · Structure
Cat. No.
A12402
CAS No.
170632-47-0
Formula
C19H16N2O2
Mol. Weight
304.34

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YC-1 (Lificiguat)

Cat. No. A12402 CAS 170632-47-0

sGC activator

YC-1 is a direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A2780 IC50 20.35 μM Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs in hypoxic condition by MTT assay [PMID: 33992863]
A2780 IC50 80 μM Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 33992863]
A498 IC50 0.3 μM Cytotoxicity against human A498 cells after 48 hrs by MTT assay [PMID: 26820553]
A498 IC50 0.3 μM Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay [PMID: 26235951]
A498 IC50 0.37 μM Cytotoxicity against human A498 cells after 48 hrs by MTT assay [PMID: 23831809]
A549 IC50 25.62 μM Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs in hypoxic condition by MTT assay [PMID: 33992863]
A549 IC50 80 μM Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 33992863]
ACHN IC50 0.3 μM Antitumor activity against human ACHN cells after 48 hrs by MTT assay [PMID: 20097456]
AGS IC50 2 μM Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human AGS cells by reporter gene assay [PMID: 17884495]
AGS IC50 2 μM Inhibition of hypoxia induced HIF1 transcriptional activity in human AGS cells by cell-based HRE reporter assay [PMID: 17328532]
HCT-116 IC50 2.2 μM Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay [PMID: 24900662]
HEK293 IC50 9.21 μM Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase reporter gene assay [PMID: 19435661]
HeLa IC50 1.2 μM Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assay [PMID: 27847273]
HeLa IC50 1.5 μM Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assay [PMID: 24900662]
HeLa IC50 2 μM Inhibition of HIF-1 (unknown origin) expressed in human HeLa cells after 12 hrs by HRE luciferase reporter gene assay 10.1039/C2MD20134H
HeLa IC50 2.4 μM Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing Renilla luciferase incubated for 12 hrs under 1% O2 condition by dual luciferase reporter gene assay [PMID: 31740202]
HeLa IC50 29.3 μM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay [PMID: 24900662]
HeLa IC50 56 μM Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs under normoxia condition by MTT assay [PMID: 31740202]
Hep 3B2 IC50 13.8 μM Inhibition of hypoxia induced HIF1-alpha transcriptional activity in human Hep3B cells by reporter gene assay [PMID: 17884495]
Hep 3B2 IC50 13.8 μM Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assay [PMID: 17328532]

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Specifications

Manufacturer Adooq Bioscience
Actions Activator
CAS Number 170632-47-0
Applications sGC activator
Formula C19H16N2O2
Molecular Weight 304.34
Synonyms Lificiguat
SMILES
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 58 mg/mL (190.57 mM)
Water Insoluble
Ethanol 58 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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