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1,1,1-Trifluoroethyl-PEG4-azide

PROTAC Linker

1,1,1-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it valuable for the development of targeted protein degradation strategies in chemical biology research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1817735-35-5
Applications	PROTAC Linker
Formula	C₁₀H₁₈F₃N₃O₄
Molecular Weight	301.26
SMILES	FC(F)(F)COCCOCCOCCOCCN=[N+]=[N-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.