1,1,1-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it valuable for the development of targeted protein degradation strategies in chemical biology research.
1,1,1-Trifluoroethyl-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it valuable for the development of targeted protein degradation strategies in chemical biology research.
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